【用戶】王瑞賢

【年級】高一上

【評論內容】整理自Foey's 7th p.534bupivacaine(1)有S、R form 為一消旋體（racemic mixture）→(A)對(2)S form(levo-)：A.為主要局部麻醉的藥理活性B.心毒性低於bupivacaine原型藥、R-form藥→(C)錯C.FDA核准上市商品名Chirocaine(CNS毒性較 ropivacaine低)(3)R form：造成心毒性附上原文Stereochemistry of the local anesthetics, however, plays an important role in their observed toxicity and pharmacokinetic properties. For example, ropivacaine and levobupivacaine, the only optically active local anesthetics currently being marketed, have considerably lower cardiac toxicities than their close structural analog, bupivacaine (...

【用戶】如果詳解被鎖找 北醫王瑞賢

【年級】高一上

【評論內容】整理自Foey's 7th p.534bupivacaine(1)有S、R form 為一消旋體（racemic mixture）→(A)對(2)S form(levo-)：A.為主要局部麻醉的藥理活性B.心毒性低於bupivacaine原型藥、R-form藥→(C)錯C.FDA核准上市商品名Chirocaine(CNS毒性較 ropivacaine低)(3)R form：造成心毒性附上原文Stereochemistry of the local anesthetics, however, plays an important role in their observed toxicity and pharmacokinetic properties. For example, ropivacaine and levobupivacaine, the only optically active local anesthetics currently being marketed, have considerably lower cardiac toxicities than their close structural analog, bupivacaine (...