49. Which of the following descriptions for Transdermal therapeutic system fentanyl (fentanyl-TTS)patches is not correct after application?
(A) a lag time of approximately 2 hours before plasma levels of fentanyl are detected anddetected therapeutic levels after 12 to 16 hours
(B) After system removal, serum fentanyl concentrations decline gradually and has an apparentt1/2 of 17 hours
(C) Prolonged exposure to heat or use in patients who are febrile can cause a toxic overdose
(D) should not be used in patients who are not opioid-tolerant, for acute pain issues
(E) All of the above are correct descriptions