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Bacitracin interferes with the dephosphorylation of C55-isoprenyl pyrophosphate, and a related molecule known as bactoprenol pyrophosphate; both of these lipids function as membrane carrier molecules that transport the building-blocks of the peptidoglycan bacterial cell wall outside of the inner membrane.After binding to lipopolysaccharide (LPS) in the outer membrane of Gram-negative bacteria, polymyxins disrupt both the outer and inner membranes. The hydrophobic tail is important in causing membrane damage, suggesting a detergent-like mode of action.[1]Removal of the hydrophobic tail ...

【終於.......】評論

多粘菌素B（英語：Polymyxin B，又名多黏菌素B）是一種主要用於治療 革蘭氏陰性菌感染藥物。它是從一種名為Bacillus polymyxa的細菌中被分離出來的。多粘菌素B是多粘菌素的一種，由兩種非常近似的化合物混合而成：多粘菌素B1和多粘菌素B2。除變形桿菌屬外，它對幾乎所有革蘭氏陰性桿菌均有殺菌作用。多粘菌素的作用原理是與細胞膜粘附，改變細胞膜的結構使之通透性變強，細胞因吸收周圍環境過多的水分而膨脹死亡。它是帶有正電荷的鹼性蛋白，像常用於去污的表面活性劑一樣。副作用包括神經毒性以及急性腎小管壞死。多粘菌素通常與脂肪酸結合，在生理條件下具有表面活性劑作用，具有親水和疏水的雙重特性多粘菌素只用於革蘭氏陰性菌感染的治療，...