Part 8. Please read the following article and answer the following questions |source: Modified from Molecular Cell (2021),doi:https://doi.org/10.1016/i.molcel.2020.12.017]The series of RNA folding events that occur during transcription can critically in/luence cellular RNA function. Here, we presentreconstructing RNA dynamics from data (R2D2). a method to uncover details of cotranscriptional RNA folding. We model thefolding of the Escherichia coli signal recognition particle (SRP) RNA and show that it requires specific local structural fluctuationswithin a key hairpin to engender efficient cotranscriptional confornational rearrangement into the functional structure. All-atommolecular dynaics simulations suggest that this rearrangement proceeds through an internal tochold-mediated strand-displacementmechanism, which can be disrupted with a point mutation hat limits local structural fluctuations and rescued with compensatingmutations that restore these fluctuations. Moreaver, a cotranscriptional folding intermediate couid be cleaved in viro byrecombinant E. coli RNase P, suggesting potential cotranscriptional processing. These results from experiment-guided multi-scalemodeling demonstrate that even an RNA with a simple functional structure can undergo compler folding and processing duringsynthesis.
【題組】28. What does "engender" indieate in the paragraph? (3%)
(A)interrupt
(B) cure
(C)dull
(D)promote