42. Which of the following statements regarding "uncompetitive inhibition" is correct?
(A)An uncompetitive inhibitor binds to the active site of an enzyme
(B) The structure of an uncompetitive inhibitor must resemble the substrate of its targeting enzyme
(C) KM of an enzyme-catalyzed reaction increases in the presence of uncompetitive inhibitors
(D) Vmax of an enzyme-catalyzed reaction increases in the presence of uncompetitive inhibitors
(E) The effect of an uncompetitive inhibitor can be observed even at high substrate concentration