問題詳情

26.下列何種情況可能導致codeine無法發揮療效?
(A)CYP2C19 rapid metabolizer
(B)CYP2D6 rapid metabolizer
(C)CYP2C19 poor metabolizer
(D)CYP2D6 poor metabolizer

參考答案

答案:D
難度:困難0.28125
統計:A(20),B(13),C(13),D(18),E(0)

用户評論

腦洞爆炸】評論

Codeine 是2D6substract

hogebrad】評論

codeine  本身就有止咳吧? 代謝後才有止痛吧.. 還是說代謝後才有止咳跟止痛?

nikisour】評論

Metabolism: Hepatic via UGT2B7 and UGT2B4 to codeine-6-glucuronide, via CYP2D6 to morphine (active), and via CYP3A4 to norcodeine. Morphine is further metabolized via glucuronidation to morphine-3-glucuronide and morphine-6-glucuronide (active).