問題詳情
83. Misfolding of protein causes a broad range of disease. Which of the following human diseaseslinked to misfolding of proteins are CORRECT? ① Alzheimer’s disease, β-Amyloid peptide ；② Creutzfeldt-Jakob disease, Prion protein ； ③ Cystic fibrosis, Superoxide dismutase I；④ Hungtington’s disease, α-Synuclein； ⑤ Familial amyloidotic polyneuropathy, Transthyretin.
(A) ①,②,③
(B) ①,②,④
(C) ②,③,⑤
(D) ③,④,⑤
(E) ①,②,⑤
參考答案
用户評論
【艾爾】評論
The most common cystic fibrosis– causing mutation is the deletion of a Phe residue at position 508 in CFTR, which causes improper protein folding. Most of this protein is then degraded and its normal function is lost .In Parkinson disease, the misfolded form of the protein -synuclein aggregates into spherical filamentous masses called Lewy bodies.