7. HMG-CoA reductase is the key regulatory site in cholesterol synthesis. Which of
the following statement about the regulatory mechanisms of HMG-CoA reductase is
TRUE?
(A) Phosphorylation by cAMP-dependent kinase activates HMG-CoA reductase,
(B) A high AMP:ATP ratio leads to activation of HMG-CoA reductase,
(C) High cholesterol level increases the half-life of HMG-CoA reductase,
(D) High cholesterol level increases HMG-CoA reductase gene expression,
(E) HMG-CoA reductase phosphatase can activate HMG-CoA reductase.