【etrnya】評論

Aciclovir is converted by viral thymidine kinase to aciclovir monophosphate, which is then converted by host cell kinases to aciclovir triphosphate (ACV-TP).[23] ACV-TP, in turn, competitively inhibits and inactivates HSV-specified DNA polymerases preventing further viral DNA synthesis without affecting the normal cellular processes.[23][33][34]ResistanceResistance to aciclovir is rare in people with healthy immune systems, but is more common (up to 10%) in people with immunodeficiencies on chronic antiviral prophylaxis (transplant recipients, people with acquired immunodeficiency syndro...

【楊雯華】評論

經磷酸化才能發揮作用

【陳育惠】評論

Acyclovir(Zoviraxâ)為非環狀鳥糞嘌呤核苷酸類似物，其被單純性疱疹病毒thymidine kinase轉變成acyclovir monophosphate，接下來細胞內之酵素再加上一個或二個磷酸根使之轉變形成 diphosphate 及triphosphate，而 acyclovir triphosphate即為活性型。Acyclovir triphosphate會干擾單純疱疹病毒的DNA polymerase，因而阻斷病毒的複製，同時增長的 DNA 鏈可能也被病毒的DNA polymerase 介入，因此終止了進一步的增長