61. 以下關於 microsatellite instability-high (MSI-H) 子宮內膜癌的描述，何者為非？
(A) Mutations in or epigenetic silencing of mismatch repair genes leading to genomicinstability and high burden of somatic mutations.
(B)Associated with mutations that upregulate signaling through the PI3K/AKT pathway.
(C)Prevalent in endometrial carcinomas arising in women with hereditary nonpolyposiscolorectal carcinoma syndrome (also referred to as Lynch syndrome).
(D)In sporadic endometrioid carcinoma, loss of DNA mismatch repair gene is commonlycaused by epigenetic silencing.