3. The innervation of deep somatic tissue like muscle and joint is quite complex. Which of thefollowing description is not appropriate?
(A) The nociceptors are predominantly activated by non-physiological stimuli which may causedamage to the structures (e.g. overload, twisting, strong pressure, ischemic contraction).information within the central nervous system.
(B) During inflammation or after trauma, nociceptors of joint and muscle show pronouncedsensitization, in particular for mechanical stimuli.
(C) Descending inhibition is enhanced during chronic inflammation but seems to be normalizedduring acute inflammation.
(D) Both primary afferent fibers as well as sympathetic reflexes may aggravate inflammatorylesions.
(E) Reduced release of hormones from the hypothalamic-pituitary-adrenal (HPA) axis such ascortisol, adrenal androgens and testosterone may cause a relative loss of anti-inflammatoryactivity.