問題詳情

58.Arylamine轉變成arylnitrenium ion之致癌性物質,與下列那個Phase II代謝反應比較無關?
(A)glucuronidation
(B)sulfonation
(C)acetylation
(D)methylation

參考答案

答案:D
難度:適中0.41115
統計:A(75),B(52),C(42),D(118),E(0)

用户評論

蕭惠珊】評論

解個鎖已解鎖Phase II代謝主要是結合反應(A)glucuronidation 醛醣酸結合(B)sulfonation 硫酸結合(C)acetylation 乙烯結合(D)methylation 甲基化線上測驗: /reponse.php?id=35494479&dostatus=&noslave=1&exp=1220#ixzz55IBN5AEj

蔬菜狗狗】評論

(A) Foye 149 "The induction of bladder carcinogensis by aromatic amines can result from the O-glucuronidation of the N-hydroxylarylamine. These O-glucuronides become concentrated in the urine where they are either hydrolyzed by the acid pH of the urine to produce N-hydroxyarylamine or eliminate water from the N-hydroxyarylamine under these acidic conditions to yield the formation of an electrophilic arylnitrenium species (5 in figure)(C) Foye p152"the tumorigenic activity of arylamines (1 in figure) can be the result of a complex series of sequential metabolic reactions commencing with N-acet...