59. Which are correct statements regarding hyperuricemia and related nephropathy?
(1)The renal tubular transporters responsible for determining how much of the filtered uric acid isactually excreted are located in the distal nephron
 (2)Renal clearance of uric acid can be inhibited by the angiotensin-converting-enzyme inhibitors or byβ-Blockers.
 (3)Initiation of colchicine can induce acute flares of gout
 (4)Initiation of allopurinol or febuxostat can induce acute flares of gout
(5)Routine use of allopurinol (100-300 mg/day) in patients with stage 3-4 CKD can slow kidney diseaseprogression 
(A) (1)+(2)+(4)+(5)。
(B) (1)+(4)+(5)。
(C) (2)+(3)。
(D) (2)+(4)。
(E) (2)+(4)+(5)。