問題詳情

66.下列那種口服藥物，若與midazolam共同使用，較不會影響其藥物的代謝？
(A)cimetidine
(B)erythromycin
(C)alcohol
(D)fluconazole

參考答案

答案：C
難度：非常困難0.127
書單：沒有書單，新增

用户評論

【Janet Tsai】評論

Midazolam 是一種鎮靜安眠藥, ...

【我的毒沒有解藥】評論

欸不是原來酒精也算口服藥物所以我天天在嗑藥

【kin】評論

Among benzodiazepines, alprazolam, triazolam, brotizolam and midazolam are mainly metabolished by CYP3A4.Potent inhibitors of CYP3A4 include clarithromycin, erythromycin, diltiazem, itraconazole, ketoconazole, ritonavir, verapamil, goldenseal and grapefruit.Fluconazole is an inhibitor of CYP3A4, CYP2C9 and 2C19 enzymes but not an inhibitor of transportersCimetidine is a potent inhibitor of certain cytochrome P450 (CYP) enzymes, including CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4.Midazolam 是一種鎮靜安眠藥, 代謝的人體酵素是 CYP3A4, cimetidine (histamine H₂ receptor antagonist), e...