【如果詳解被鎖找 北醫王瑞賢】評論

【解題】整理自7th Foey's p.1360、1361內文(A)C3、17氧化的官能基(ex：ketone)，通常不是必要的          →因基本結構(5a-androstane)就有雄性激素的活性(B)修飾成5β-H→使A/B環變成cis結構→失去雄性激素活性(C)修飾成3α-OH、3-keto可增加雄性激素活性(D) 修飾成17α-OH後，會失去雄性激素活性【附上原文】(A) Oxygen functional groups normally occurring at positions 3 and 17 of the steroid ring system are not essential, because the basic nucleus, 5a-androstane, has androgenic activity (B)hydrogen is in the 5b-position, thereby affording a cis A/B ring juncture, no active androgens and anabolic agents are ...