【HSU CHEN NING】評論

免疫抑制劑：cyclosporin A、FK506(Tacrolimus)機轉：抑制calcineurin，T cell訊息傳遞受阻

【7you】評論

免疫抑制劑Cyclosporine Calcineurin inhibitor whichimpairs IL-2 production and releaseimpairs IL-2-induced T-cell activationTacrolimus (FK506) Calcineurin inhibitor via binding with intracellular FKBP-12 protein whichimpairs IL-2 production and releaseimpairs IL-2-induced T-cell activationSirolimus (Rapamycin)mTOR inhibitor via binding with intracellular FKBP-12 protein which↓ cytokine-induced T-cell proliferationBasiliximabTargets the α-chain of the IL-2 receptor complex whichis expressed on activated T-cellsAzathioprine A precursor of 6-mecaptopurine whichinhibits purine nucleotide synthesis incorporates itself into the cell's DNA and halts replicationMycophenolate mofetilInosine monophosphate dehydrogenase (IMPDH) inhibitor which impairs guanosine nucleotide synthesisCorticosteroidsNF-κB inhibitorInduces T-cell apoptosis