【用戶】JANZ
【年級】高二下
【評論內容】第二代的抗組織胺藥物與CYP3A4抑制劑(ex.macrolide antibiotics, ketoconazole, itraconazole)併用,會使第二代的抗組織胺藥物之血中濃度明顯上升,因而顯著阻斷心臟HERG(Ikr)鉀離子通道,及使動作電位顯著延長,會引起致命性心室心律不整(kethal ventricular arrythmias)
【用戶】Swear
【年級】幼稚園下
【評論內容】macrolide antibiotics (Clarithromycin, erythromycin...) + anti-histamine (astemizole, terfenadine) --- CYP3A4 受抑制,anti-histamine 濃度增加 --- QT-interval prolong (in ECG). --- arrhythmia
【用戶】Swear
【年級】幼兒園下
【評論內容】macrolide antibiotics (Clarithromycin, erythromycin...) + anti-histamine (astemizole, terfenadine) ---> CYP3A4 受抑制,anti-histamine 濃度增加 ---> QT-interval prolong (in ECG). ---> arrhythmia