66.下列何者為 nateglinide 之主要代謝物?
(A)




【過過小藥師】評論
這是考古題!!!!(以為這種偏題不會那麼...
【terminator812】評論
複習一下糖尿病的藥理...
【洪峻澤】評論
附上Foye課本的圖...
【激烈的小學姊】評論
Nateglinide is a phenylalanine analogue of meglitinide where the benzoic acid carboxylate group is transposed to the α-carbon of the N-ethyl side chain, creating the amino acid functionality. Nateglinide binds selectively to the SUR1 on β-cells and has a much lower affinity for cardiac and skeletal muscles. 63 It is a chiral molecule synthesized as the S( +)-isomer with traces of the R(-)-isomer as an impurity. The S( +)-isomer is 100-fold more potent than the R(-)-isomer. Nateglinide is a rapidly absorbed insulin secretagogue that has a mechanism of action similar to that of repaglinide, wi...