2.The DNA polymerases are the workhorses for replication of genomicinformation in living cells. Which of the following descriptions about theirbiotechnological applications is not correct?
(A) During polymerase chain reaction (PCR), DNA polymerases often extendmisprimed targets and primer-dimers, which are common sources of nonspecificamplification.
(B) During PCR, hot-start DNA polymerases reduce nonspecific amplification,increase yields, and allow convenient room temperature setup for high-throughputapplications.
(C) Although archaeal DNA polymerases are extremely heat-stable, they may bcslow in synthesizing DNA due to lower processivity.
(D) High-fidelity DNA polymerases are enzymes with strong proofreading activitybased on their 3'→5' exonuclease activity.
(E) DNA polymerases can be engineered with high specificity by introducing astrong DNA-binding domain of another protein without compromising polymeraseactivity.