問題詳情

41.下列關於thrombomodulin的敘述，何者正確？
(A)參與抑制Factor VIII
(B)參與抑制Tissue factor
(C)參與活化Factor V
(D)參與抑制Plasminogen activator inhibitor-1

參考答案

答案：A
難度：適中0.599206
統計：A(151),B(20),C(34),D(47),E(0)

用户評論

【etrnya】評論

Thrombomodulin (TM), CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin. Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin.Protein C is a major component in anticoagulation in the human body. It acts as a serine protease zymogen: APC proteolyses peptide bonds in activated Factor V and Factor VIII (Factor Va and Factor VIIIa), and one of the amino acids in the bond is serine....

【簡妤軒】評論

thrombomodulin與thrombin結合形成complex，然後活化protein C ，再去抑制5因子8因子