問題詳情

41.下列何種藥物主要以acetylation的方式代謝？
(A)indomethacin
(B)lidocaine
(C)acetaminophen
(D)procainamide

參考答案

答案：D
難度：困難0.285714
統計：A(5),B(2),C(3),D(4),E(0)

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【解題】整理自7th Foey's 內文(A)Indomethacin    ： N-Deacylation(B)Lidocaine            ：N-dealkylation、N-oxidation、Hydrolysis(C)Acetaminophen ：O-glucuronide 、O-sulfate、 Oxidation 、Conjugation(D)Procainamide     ：N-acetylation【附原文】節錄自7th Foey's 內文(A)P.186表格O-demethylation N-deacylation of p-chlorobenzoyl group Both O-dealkylation and N-deacylation Conjugation of phenolic products with glucuronic acid Other conjugation products(B)P.187表格N-dealkylationOxidative cyclization to a 4-imidazolidoneN-oxidation of amide N Aromatic hydroxylation ortho to methyl Hydrolys...