【用戶】梅雷翁
【年級】大四下
【評論內容】Polyarteritis: “Beagle Pain Syndrome.” Polyarteritis is a disease that occurs sporadically in many animal species and is an important disease of aged rats called polyarteritis nodosa (E-Fig. 10-32). Many recent reports have described the occurrence of polyarteritis in a disease termed idiopathic necrotizing polyarteritis (idiopathic canine polyarteritis, juvenile polyarteritis syndrome) involving multiple arteries, including the coronary and meningeal arteries in dogs, most often pet and laboratory beagle dogs (“beagle pain syndrome”). Clinically, affected dogs typically show recurrent episodes of fever, body weight loss, and occasionally cervical pain manifested by a stilted gait and stiff neck with a hunched body posture. However, some affected dogs do not display clinical signs of disease. The lesions are usually attributed to an immune-mediated vascular injury. Small and medium-sized muscular arteries in a wide variety of organs, including the heart, meninges, epididymis, and thymus, are selectively involved and grossly appear thick and tortuous, have associated focal hemorrhage, and develop aneurysms and thrombo- sis. Microscopically, the early lesions include fibrinoid necrosis and leukocytic invasion of the intima and media (E-Fig. 10-33). In chronic lesions, inflammatory cells and fibrosis involve all layers of the vascular wall. 多發性動脈炎（polyarteritis）好發於米格魯犬（beagle pain syndrome）、老年大鼠症狀：發燒、體重減輕、脖子痛、步伐僵硬、拱背病變在血管中層、內層，有纖維素性壞死和白血球浸潤。在慢性病灶中血管各層皆出現纖維化病因：免疫媒介性血管損傷常發生在各臟器（心臟、腦膜）的中等大小的肌肉性動脈，使血管增厚、扭曲、局部出血，進而產生動脈瘤、血栓 多發性動脈炎又稱米格魯疼痛症候群，可發生在老年大鼠與其他動物，患畜可見發燒、消瘦、頸部疼痛、病變以fibrinoid necrosis為主，發生於血管中層及內層Ref: Pathologic Basis of Veterinary Disease25.多發性結節性動脈炎（polyarteritis nodosa）好發的部位為何？(A)腦、肺及心(B)脾、腎及胃(C)肺、肝及心(D)心、腎及腦編輯私有筆記及自訂標籤
【用戶】梅雷翁
【年級】大四下
【評論內容】Polyarteritis: “Beagle Pain Syndrome.” Polyarteritis is a disease that occurs sporadically in many animal species and is an important disease of aged rats called polyarteritis nodosa (E-Fig. 10-32). Many recent reports have described the occurrence of polyarteritis in a disease termed idiopathic necrotizing polyarteritis (idiopathic canine polyarteritis, juvenile polyarteritis syndrome) involving multiple arteries, including the coronary and meningeal arteries in dogs, most often pet and laboratory beagle dogs (“beagle pain syndrome”). Clinically, affected dogs typically show recurrent episodes of fever, body weight loss, and occasionally cervical pain manifested by a stilted gait and stiff neck with a hunched body posture. However, some affected dogs do not display clinical signs of disease. The lesions are usually attributed to an immune-mediated vascular injury. Small and medium-sized muscular arteries in a wide variety of organs, including the heart, meninges, epididymis, and thymus, are selectively involved and grossly appear thick and tortuous, have associated focal hemorrhage, and develop aneurysms and thrombo- sis. Microscopically, the early lesions include fibrinoid necrosis and leukocytic invasion of the intima and media (E-Fig. 10-33). In chronic lesions, inflammatory cells and fibrosis involve all layers of the vascular wall. 多發性動脈炎（polyarteritis）好發於米格魯犬（beagle pain syndrome）、老年大鼠症狀：發燒、體重減輕、脖子痛、步伐僵硬、拱背病變在血管中層、內層，有纖維素性壞死和白血球浸潤。在慢性病灶中血管各層皆出現纖維化病因：免疫媒介性血管損傷常發生在各臟器（心臟、腦膜）的中等大小的肌肉性動脈，使血管增厚、扭曲、局部出血，進而產生動脈瘤、血栓 多發性動脈炎又稱米格魯疼痛症候群，可發生在老年大鼠與其他動物，患畜可見發燒、消瘦、頸部疼痛、病變以fibrinoid necrosis為主，發生於血管中層及內層Ref: Pathologic Basis of Veterinary Disease25.多發性結節性動脈炎（polyarteritis nodosa）好發的部位為何？(A)腦、肺及心(B)脾、腎及胃(C)肺、肝及心(D)心、腎及腦編輯私有筆記及自訂標籤