問題詳情

25. Adenosine deaminase (ADA) deficiency is an inherited disorder that damages theimmune system and causes severe combined immunodeficiency (SCID). All of thefollowing steps were performed for gene therapy when a patient with defective ADAwas treated. Except?
(A) Human leukocyte antigen (HLA) testing should be performed before genetherapy.
(B) Haematopoietic stem cells were collected from the patient's bone marrow.
(C) CD34 positive cells were transduced with a viral vector expressing functionalADA.
(D) The transfected cells were grown in culture to ensure ADA gene is active.
(E) The transfected cells are reinfused into the same patient.

參考答案

答案：A
難度：計算中-1
書單：沒有書單，新增

用户評論

【用戶】你到別的地方去耍笨好不好

【年級】高三下

【評論內容】腺苷脫氨酶 (ADA) 缺乏症是一種遺傳性疾病，會損害免疫系統並導致嚴重的聯合免疫缺陷 (SCID)。 當治療 ADA 缺陷患者時，執行以下所有步驟進行基因治療。 除了？(A) 基因治療前應進行人類白細胞抗原 (HLA) 檢測。不需要(B) 從患者的骨髓中採集造血幹細胞。(C) 用表達功能性 ADA 的病毒載體轉導 CD34 陽性細胞。(D) 轉染的細胞在培養物中生長以確保 ADA 基因具有活性。(E) 轉染的細胞被重新註入同一患者體內。HLA 是體內大多數細胞上的蛋白質或標誌物。免疫系統使用 HLA 來查看哪些細胞屬於外來物質。