18. About Near Attack Conformation (NAC), which of the following is NOT true?
(A) Computer simulations find that the chance of NAC to form in the enzyme active site can be 300,000 times larger than that of NAC in the absence of the enzyme
(B) the energy difference of E.NAC→E.X+ is smaller than that of NAC→X+ where X+ means the transition state
(C) The enzymatic catalysis benefits from lowering the energy barrier of S→NAC
(D) The transition state analog has a configuration closer to the transition state than the NAC
(E) Both the catalyzed and uncatalyzed reactions require the formation of NAC