問題詳情

70.下列有關利尿劑triamterene與amiloride的敘述，何者錯誤？
(A)triamterene具有pteridine環
(B)amiloride具有aminopyrazine環
(C)triamterene代謝物4'-hydroxytriamterene仍具利尿活性
(D)triamterene的鹼性比amiloride強

參考答案

答案：D
難度：適中0.454545
統計：A(0),B(2),C(4),D(5),E(0)

用户評論

【用戶】如果詳解被鎖找 北醫王瑞賢

【年級】高一上

【評論內容】【解題】整理自7th Foey's p.743內文(A) PTERIDINES: TRIAMTERENE(B) AMINOPYRAZINES: AMILORIDE(C) 4'-OH、Conjugate代謝物皆具有利尿活性(D)Amiloride鹼性較Triamterene強(D) The greater potency (approximately 100-fold in vitro) of amiloride is probably due to the fact that it is a stronger base (pKa = 8.7) and is therefore more extensively protonated at physiologic pH than triamterene (pKa = 6.2).【延伸學習 & 國考複習】(完整表格詳見北醫藥學103級藥理藥化統整本 3.0 P150、151)國考考過1.結構：Amiloride(Aminopyrazine)、Triamterene(★Pteridine)2.副作用：高血鉀3.臨床用途：皆可治假性醛固酮增多症(Liddle’s ...