28. Bextra, a COX-2 inhibitor used in the treatment of arthritis, contains a heterocyclic ring. What
29. Which of the following halides has the greatest rate toward nucleophilic aromatic substitution?
30. Provide the major product in the oxidation of n-butylbenzene with KMnO4.
31. Which of the following diols cannot be cleaved by periodic acid?
32. A primary kinetic isotope effect could most likely to be observed in which of the following mech
33. Rank the following compounds in an order of decreasing rate in an E2 reaction. (A) A > B >
34. Provide the structure of the major product which results in the following reaction. (E) no rea
35. Provide the organic product(s) of the reaction shown below. (A)Ⅰ (B) Ⅱ (C) Ⅲ (D) Ⅰ and Ⅱ (E) Ⅰ
36. What is the major product of the following reaction? (A) 4-ethyl-2,3-dimethyl-2-propylpyridine
37. What is the major product of the following reaction? (E) none of the above
38. Provide reagents to complete the following reaction. (A) DEAD, PPh3 (B) H2SO4 (C) NaOH (D) DMSO
39. The final product would you expect from the following sequential reactions from p-toluidine. (A
40. What is the major product of the following reaction sequence?
41. What is the major product of the following reaction?
42. What is the major product of the following reaction?
43. What is the major product of the following reaction?
44. What is the major product from the following reaction?
45. What product would be obtained from the following reaction?
46. What will be the product of the following transformations?
47. What is the major product of the following transformations? (E) none of the above
48. Provide the organic product of the reaction shown below.
49. What is the final product of the following sequential reactions?
50. What is the product of the following reaction sequence?
51. What is the final major product of the following transformations?
52. Which of the following reaction conditions could not be used in the following transformation?