【評論主題】2 下列何者可用為當犬貓誤食抗凍劑ethylene glycol 中毒時之解毒劑？(A) ascorbic acid(B) ethanol(C) penicillamine(D) vitamine K

【評論內容】EG is rapidly absorbed from the GI tract; in dogs, peak blood concentrations of EG occur within 3 hr of ingestion. Approximately 50% of ingested EG is excreted unchanged by the kidneys; however, a series of oxidation reactions in the liver and kidneys metabolize the remaining EG. Toxic metabolites of EG cause severe metabolic acidosis and renal tubular epithelial damage.

The prognosis varies inversely with the amount of time that elapses between ingestion and initiation of treatment. Treatment is aimed at decreasing absorption of ingested EG, increasing excretion of unmetabolized EG, preventing...