【評論主題】69.下列何種藥物不會增加warfarin的藥效？(A)fluoxetine(B)trazodone(C)sertraline(D)venlafaxine

【評論內容】warfarin - trazodone

One case report has suggested that trazodone may reduce prothrombin and partial thromboplastin times. The mechanism and clinical significance are unknown. Similar effects may occur with other oral anticoagulants. The patient's PT or INR should be observed for alterations. An increase in oral anticoagulant dosage may be necessary. Patients should be advised to promptly report any signs of blood clots (e.g. chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity).

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