【評論主題】75.下列何種藥品與allopurinol併用時，較不會發生交互作用？(A)azathioprine(B)captopril(C)warfarin(D)omeprazole

【評論內容】

(C) Warfarin & allopurinol

warfarin (1A2 substrate), allopurinol (1A2 inhibitor)

Exposure to warfarin (or another coumarin-derivative anticoagulant) might be increased, resulting in an increased INR, when coadministered with allopurinol, a CYP1A2 inhibitor.

[ref. micromedex]