用戶【Chi ᵕ̈】點評問題和點評內容

【評論主題】46.下列何者最不建議用於治療neonatal seizures? (A)phenobarbital (B)valproic acid (C)phenytoin (D)lorazepam

【評論內容】

Valproic acid可能造成新生兒神經管缺陷

【評論主題】6.有關藥品與包裝標示之警語配對,下列何者最不適當? (A)verapamil-不可與葡萄柚汁併服 (B)famotidine-應空腹服用 (C)pseudoephedrine-避免在睡前服用 (D

【評論內容】(A) verapamil-不可與葡萄柚汁併服(B) famotidine-應空腹服用(C) pseudoephedrine-避免在睡前服用

有些藥物反而會影響睡眠,像支氣管擴張劑(theophylline)、緩解鼻塞的偽麻黃鹼(pseudoephedrine)等

Ref. 新北市藥師公會

(D) chlorpheniramine-服藥後,避免開車或操作危險機械

CNS depression: May cause CNS depression, which may impair physical or mental abilities; patients must be cautioned about performing tasks which require mental alertness (eg, operating machinery or driving).

Ref. UptoDate

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【評論主題】2.下列何者可做為眼藥水之增稠劑(viscosity enhancer)? (A)chlorhexidine acetate (B)phenylmercuric nitrate (C)hyprome

【評論內容】

(A)chlorhexidine acetate →防腐劑preservatives

     https://app.yamol.tw/item/1384198

(B)phenylmercuric nitrate →防腐劑preservatives

    Long-term use of eye-drops containing phenylmercuric nitrate as a preservative

    Ref. Meyler's Side Effects of Drugs (Sixteenth Edition), 2016

(C)Hypromellose→hydroxypropyl methylcellulose (HPMC)增稠劑

(D)chlorobutanol →防腐劑preservatives

【評論主題】4.有關raloxifene於骨鬆症治療之敘述,下列何者錯誤? (A)須考量靜脈栓塞病史 (B)依creatinine clearance調整劑量 (C)須注意與cholestyramine之交互作

【評論內容】(A) 須考量靜脈栓塞病史(B) 依creatinine clearance調整劑量(C) 須注意與cholestyramine之交互作用(D) 須考量肺栓塞之風險 [US Boxed Warning]: Raloxifene may increase the risk for deep vein thrombosis and pulmonary embolism (A)(D); use is contraindicated in patients with history of or current venous thromboembolic disorders          Ref. UptoDateDosing: Kidney Impairment: AdultCrCl ≤50 mL/minute: There are no dosage adjustments (B) provided in the manufacturer’s labeling; use with caution.          Ref. UptoDateConcurrent use of CHOLESTYRAMINE and RALOXIFENE may result in reduc...