【666】評論

(A) 對於第一期攝護腺癌，若癌細胞分化良好，僅局限於小範圍，而且依照病人身體條件考量可能有其他的共病更會在餘生中造成更大生命威脅時，可以考慮積極監測，主要是定期以攝護腺特異抗原為追蹤工具。(B) 睪丸切除或LHRH agonist可用於advanced（stage D2）前列腺癌(C) androgen deprivation therapy (ADT)藥物治療最常用GnRH agonist，替代用藥可用GnRH antagonist(Androgen deprivation therapy (ADT) is acomponent of the initial approach for patients when systemic therapy isindicated for metastatic prostate cancer or when evidence of disseminateddisease is based upon an elevated or rising serum prostate-specific antigen(PSA). ADT can be accomplished either with bilateral orchiectomy (surgicalcastration) or by medical castration.)(D) abiraterone 也可治療不具抗性的藥理機轉: selectively and irreversibly inhibits CYP17(17 alpha-hydroxylase/C17,20-lyase), an enzyme required for androgenbiosynthesis which is expressed in testicular, adrenal, and prostatic tumortissues. Inhibits the formation of the testosterone precursors適應症: Prostate cancer, metastatic1.metastatic, high-risk castration-sensitive2.metastatic, castration-resistant

【傑德】評論

(A)不能因為疾病進展緩慢，就將「觀察」...

【Tomyang 羊蹄】評論

GnRH抑制劑可以用degarelix SC 不會有初期使用腫瘤加劇的問題BTW abiraterone 與enzalutamide使用的標準一樣藥物或手術去勢抗性的轉移性前列腺癌，且在雄性素去除療法失敗後屬無症狀或輕度症狀而不須使用化學治療者.藥物或手術去勢抗性的轉移性前列腺癌且已接受過 docetaxel 治療者

【葛根葛格】評論

前列腺癌治療順序：(1)★★★★- ☆....

【jamie huang】評論

LHRH agonist 長期使用會negative feedback 抑制（短期會造成睪固酮上升