【Hui-Fang Chen】評論

Kaletra (lopinavir/ritonavir) 是lopinavir 和ritonavir 的複方製劑。Lopinavir 是一種人類免疫不全病毒 HIV-1 及HIV-2 蛋白酉每 (protease) 的抑制劑。Kaletra 複方製劑中所含的ritonavir 可以抑制lopinavir 被CYP3A ( 細胞色素 P450 3A) 代謝，所以可以增加lopinavir 的血漿濃度。Ritonavir was originally developed as an inhibitor of HIV protease. It is one of the most complex inhibitors. It is now rarely used for its own antiviral activity, but remains widely used as a booster of other protease inhibitors. More specifically, ritonavir is used to inhibit a particular liver enzyme that normally metabolizes protea...

【Yun】評論

med data speaks https://meddataspeaks.wordpress.com/2014/05/11/%E8%87%A8%E5%BA%8A%E8%97%A5%E5%AD%B8-hiv%E8%97%A5%E7%89%A9%E6%B2%BB%E7%99%82%E5%B0%8F%E6%95%B4%E7%90%86/

【ling】評論

ritonavir是CYP3A4強力抑制劑。所以會併用其他PI，增強藥效和延長半衰期。