問題詳情

17 下列對細胞週期具專一性作用之抗代謝性藥物中，何者主要用於治療急性骨髓細胞性白血病（acute myelocytic leukemia）？
(A) Lomustine
(B) Cytarabine
(C) Mitomycin
(D) Daunorubicin

參考答案

答案：B
難度：適中0.598131
統計：A(10),B(64),C(12),D(21),E(0)

用户評論

【用戶】Bryan

【年級】國三上

【評論內容】Cytarabine or cytosine arabinoside is a chemotherapy agent used mainly in the treatment of cancers of white blood cells such as acute myeloid leukemia and non-Hodgkin lymphoma. It is also known as Ara-C. It kills cancer cells by interfering with DNA synthesis.

【用戶】Bryan

【年級】國三上

【評論內容】Cytarabine or cytosine arabinoside is a chemotherapy agent used mainly in the treatment of cancers of white blood cells such as acute myeloid leukemia and non-Hodgkin lymphoma. It is also known as Ara-C. It kills cancer cells by interfering with DNA synthesis.

【用戶】莉鯊

【年級】高三下

【評論內容】(A) Lomustine (CCNU)PO給藥，可過BBB → 治腦瘤機轉：Alkylation：DNA Guanine N7 cross-linking水解產物進行Protein carbamoylationDNA Guanine O6 alkylation形成G-C crosslink → 細胞毒性(B) Cytarabine（cytosine arabinoside；ara-C）IV給藥，不過BBB和 6-TG 併用治療急性非淋巴細胞白血病副作用：小腦運動失調、口腔炎、骨髓抑制經代謝形成ara-CTP，在 S phase時插入DNA而終止序列增長，抑制DNA/RNA聚合酶(D) Daunorubicin (小紅莓)IV給藥，不過BBB結合到細胞膜上治療肝癌血管栓塞、膠質母細胞瘤副作用：心毒性(國考考了N遍吧)、紅尿、骨髓抑...