【Chris】評論

Certain fundamental changes in cell physiology contribute to development of the malignant phenotype:• Self-sufficiency in growth signals (proliferation without external stimuli)• Insensitivity to growth-inhibitory signals• Evasion of apoptosis• Defects in DNA repair• Limitless replicative potential (related to telomere maintenance)• Sustained angiogenesis to provide adequate nutrition and waste removal• Ability to invade and metastasize• Ability to escape immune recognition and regulatio...