【用戶】182.4
【年級】大二上
【評論內容】sitagliptin(DPP4 inhibitor):Metabolism (肝)Metabolism by CYP3A4 and, to a lesser degree, CYP2C8 is a minor pathway in the Cl of sitagliptin.Elimination (主要為腎)Terminal t ½ is approximately 12.4 h. Approximately 13% is excreted in feces and 87% in urine via active tubular secretion (79% as unchanged drug). Sitagliptin is a substrate for organic anion transport.副作用:鼻咽炎、上呼吸道感染、腹瀉、噁心和頭痛。
【用戶】smileching
【年級】大一下
【評論內容】補充Sitagliptin:腎功能不全需要調整劑量CrCl劑量>50 mL/min每日一次100 mg30~50 mL/min每日一次50 mg<30 mL/min、ESRD血液透析腹膜透析每日一次25 mg參考資料:仿單http://www.ktgh.com.tw/Public/tbDrug/201101061620547055.pdf
【用戶】草薙素子
【年級】小一下
【評論內容】(A)腎衰病人使用 Biguanide 類增敏劑:Metformin,乳酸性酸中毒的風險會增加。(B)(C)第二代 Sulfonylurea 類促泌劑:Glimepiride、Glyburide 雖然主肝臟代謝,但仍應根據腎衰程度小心使用,尤其更不該再併用同類藥。截取自:《2015台灣慢性腎臟病臨床診療指引》(D)腎衰竭病人即使到 ESRD 都可使用 DPP-4 inhibitor ,頂多需要降劑量(Linagliptin 甚至可以不用調降)。其降血糖效果不但不受腎功能影響,甚至有潛在的腎保護功能(降蛋白尿)。
【用戶】HUSpiTLE
【年級】大二上
【評論內容】sitagliptin(DPP4 inhibitor):Metabolism (肝)Metabolism by CYP3A4 and, to a lesser degree, CYP2C8 is a minor pathway in the Cl of sitagliptin.Elimination (主要為腎)Terminal t ½ is approximately 12.4 h. Approximately 13% is excreted in feces and 87% in urine via active tubular secretion (79% as unchanged drug). Sitagliptin is a substrate for organic anion transport.副作用:鼻咽炎、上呼吸道感染、腹瀉、噁心和頭痛。