【終於.......】評論

(A)新生犢牛免疫力低下或發生消化障礙時，則可能因大腸桿菌過度增殖或毒素的生成而發病。Vero cell cytotoxins and cytotonic enterotoxins produced by E. coli are toxic proteins, which have been implicated in a number of specific diseases in humans and animals. (B)These toxins are enterotoxic as well as cytotoxic. SLTs produced in the intestine are absorbed into the blood stream and affect vascular endothelial cells in target organs. (C)理學：(1) 急性型：以腹腔臟器發生病變為主。肝、脾腫大，顯微下可見灰色壞死灶，膽囊發炎。胃黏膜、腸黏膜、腸系膜淋巴結及腎被膜下充出血，並有卡他性出血性腸炎發生。(2) 慢性型：病理變化以肺臟為主。肺臟表面有纖維素樣物質粘連、肺臟質地堅硬。(D)肉眼病變：多侷限於消化道後段及相關淋巴結，尤以迴腸末段和盲腸、結腸的起始部分為主。腸壁明顯增厚3-4倍，黏膜面潮紅且因增厚形成許多皺摺。較嚴重病例可見有動脈硬化之病變。顯微病變：腸繫膜淋巴結呈現肉芽腫性炎症反應。腸道黏膜固有層由於類上皮細胞大量增生而增厚，並可見多核巨大細胞。類上皮細胞之細胞質內可見抗酸性染色呈陽性之短桿狀分枝桿菌。參考：https://rumdise.nvri.gov.tw/fmodule/disSheet.aspx?id=VaAQwceesDE%3D參考：Escherichia coli cytotoxins and enterotoxins參考：https://vettech.nvri.gov.tw/view.php?theme=web_structure&id=1445參考：https://rumdise.nvri.gov.tw/fmodule/disSheet.aspx?id=k2xuVXQlEGk%3D參考：https://vettech.nvri.gov.tw/view.php?theme=web_structure&id=1175參考：https://rumdise.nvri.gov.tw/fmodule/disSheet.aspx?id=nHSCHGw1XLY%3D參考：https://vettech.nvri.gov.tw/view.php?theme=web_structure&id=1338