問題詳情

23.下列何者與酒精併用可能會引起disulfiram-like reaction?
(A)phenobarbital
(B)isoniazid
(C)cefoperazone
(D)verapamil

參考答案

答案:C
難度:非常困難0
統計:A(1),B(0),C(0),D(0),E(0)

用户評論

乳音奶頭嗲雞大狒狒】評論

A number of case reports describe the development of signs and symptoms consistent with a disulfiram-like reaction during coadministration of alcohol and various cephalosporins, including cefoperazone, cefamandole, cefotetan and moxalactam. The common link between these cephalosporins is the presence of a methyltetrazolethiol (MTT) sidechain in the chemical structure of the drug. Cephalosporins lacking this sidechain do not appear to be associated with this interaction. A mechanism for this interaction is unclear. It seems possible that the drugs inhibit acetaldehyde dehydrogenase, thus inhib...