【Jason Chen】評論

(C)活化p-glycoprotein expression

【ning】評論

steroid xenobiotic receptor The steroid and xenobiotic receptor (SXR) (also known as pregnane X receptor or PXR) is a nuclear hormone receptor activated by a diverse array of endogenous hormones, dietary steroids, pharmaceutical agents, and xenobiotic compounds. SXR has an enlarged, flexible, hydrophobic ligand binding domain (LBD) which is remarkably divergent across mammalian species and SXR exhibits considerable differences in its pharmacology among mammals. The broad response profile of SXR has led to the development of "the steroid and xenobiotic sensor hypothesis". SXR has been est...

【王瑜】評論

p-glycoprotein 是一種外排蛋白如果外排蛋白被抑制的話 療效會上升