問題詳情

67.有關療劑監測之敘述,下列何者正確?
(A)腎移植後使用cyclosporine,須經3~5個t1/2達steady-state後,再開始監測血中濃度
(B)sirolimus須監測steady-state 服藥後2小時的濃度
(C)tacrolimus開始併用sirolimus時,不須降低tacrolimus劑量,並維持相同血中濃度
(D)everolimus用於器官移植,須監測steady-state谷濃度

參考答案

答案:D

統計:A:333,B:64,C:17,D:515,E:0

難度:適中

用户評論

HO】評論

(A)cyclosporine TDM 建議器官移植,投與藥物初期需要每天監測Cyclosporine trough level雖然尚未達到穩定狀態,但可以預防毒性的發生並及時調整劑量始將療效最佳化原文中提到During the early postoperative period, cyclosporine levels should be measured daily, keeping in mind that these may not reflect steady-state concentrationscyclosporine monitoring is necessary less frequently and eventually only every1 to 2 months.