【用戶】Bryan
【年級】國三上
【評論內容】Antiadrenergic agents, centrally acting: Methyldopa (L-α-Methyl-3,4-dihydroxyphenylalanine; Aldomet, Aldoril, Dopamet, Dopegyt, etc.) is an alpha-adrenergic agonist (selective for α2-adrenergic receptors)
【用戶】Bryan
【年級】國三上
【評論內容】Antiadrenergic agents, centrally acting: Methyldopa (L-α-Methyl-3,4-dihydroxyphenylalanine; Aldomet, Aldoril, Dopamet, Dopegyt, etc.) is an alpha-adrenergic agonist (selective for α2-adrenergic receptors)
【用戶】大家不要鎖嘛
【年級】大三上
【評論內容】記得Methyldopa是α2 agonist這題就可以秒選~詳細機轉過程：1.被transporter送到腦中2.酵素代謝成α-methyldopamine 和 α-methylnorepinephrine3.被身體誤認成是DOPA，送進突觸小泡參與"DOPA→dopamine→norepinephrine"的生合成過程4.小泡中真正的norepinephrine變少，到達突觸後小泡釋放假的神經傳遞物(false transmitter) α-methylnorepinephrine5.雖然取代了norepinephrine，但α-methylnorepinephrine是強α agoist，所以還是會讓神經傳遞訊息、刺激中樞 α receptor，使血管收縮產生降壓效果補充Methyldopa考點適合腎功能不全、孕婦高血壓副作用會中樞鎮靜、嗜睡、溶血性貧血(Coombs test 陽性...