問題詳情

【題組】78.承上題，該藥品須降低劑量的原因為下列何種酵素被抑制？
(A) CYP3A4
(B) monoamine oxidase
(C) xanthine oxidase
(D) aldehyde dehydrogenase

參考答案

答案：C
難度：非常簡單0.907817
統計：A(41),B(21),C(1231),D(13),E(0)

用户評論

【となりのトトロ】評論

A) CYP3A4 肝酵素(常見藥物交惡作用)B) Monoamine Oxidase Inhibitors, MAOIs(單胺氧化酶抑制) 為一類抑制單胺氧化酶作用的藥物。該類藥品在抑鬱症的治療中已有很長的一段歷史。單胺是指Norepinephrine(NE)、Epinephrine、Serotonine(5-HT)、Tyramine

【Chelsea Chen】評論

AZA代謝途徑包括XO，與allopurinol 並用會增加AZA 濃度the metabolism of mercaptopurine (MP), or its prodrug azathioprine (AZA), occurs via 3 primary pathways: oxidation to inactive thiouric acid catalyzed by xanthine oxidase (XO); methylation to inactive methyl-mercaptopurine catalyzed by thiopurine S-methyl transferase (TPMT); and activation to thioguanine nucleotides in a process initiated by hypoxanthine-guanine phosphoribosyl transferase. Inhibition of XO by allopurinol may increase systemic MP exposure and toxicity, particularly via inhibition of its presystemic metabolism. US prescribing in...