【北醫王瑞賢國考統整衝刺講義】評論

koda and kimble 50 章52頁repaglinide和digoxin、warfarin皆無藥物動力學上的交互作用repaglinide由CYP2C8、3A4代謝並用Gemfibrozil會造成低血糖cyclosporine、clopidogrel 是CYP3A4代謝，競爭代謝使Repaglinide濃度上升附上原文1.Studies have shown that repaglinide has no pharmacokinetic effects on digoxin or warfarin2. Repaglinide is metabolized by CYP2C8 and3A4.3. Gemfibrozil should be avoidedin combination with repaglinide owing to the risk of hypoglycemia.

【保佑二階順利】評論

repaglinide幾乎完全經由肝臟代★，...

【可不可】評論

解題重要觀念[Repaglinide主要由CYP3A4、CYP2C8代謝](A)因為Clopidogrel代謝物是2C8的抑制劑，所以Repaglinide血中濃度上升。資料取自 MicromedexClopidogrel Metabolism1.Hepatic: Extensive2.Thiol derivative (major): Active; metabolism differs based on CYP2C19 genotype, affecting the degree of antiplatelet effect.(以前藥理藥化考這裡) A poor metabolizer has 2 nonfunctional alleles. The approximate frequencies of poor CYP2C19 metabolizer genotypes are 2% in white patients, 4% in Black patients, and 14% in Chinese patients 3.Clopidogrel: Substrate of CYP2C19, CYP1A2.....看完整詳...

【不讀書，靠拜拜】評論

(B)

【Lawrence】評論

Repaglinide是肝排，Digox☆☆ ...

【AL】評論

61 下列用藥指導的敘述，何者正確？