【7you】評論

免疫抑制劑 Mycophenolate Mofetil器官移植後免疫抑制劑inosine monophospphate dehydrogenase抑制劑抑制T-淋巴球的增生免疫抑制劑&作用標的&機制https://step1.medbullets.com/immunology/105068/immunosuppressive-drugsCyclosporine Calcineurin inhibitor whichimpairs IL-2 production and releaseimpairs IL-2-induced T-cell activationTacrolimus (FK506) Calcineurin inhibitor via binding with intracellular FKBP-12 protein whichimpairs IL-2 production and releaseimpairs IL-2-induced T-cell activationSirolimus (Rapamycin)mTOR inhibitor via binding with intracellular FKBP-12 protein which↓ cytokine-induced T-cell proliferationBasiliximabTargets the α-chain of the IL-2 receptor complex whichis expressed on activated T-cellsAzathioprine A precursor of 6-mecaptopurine whichinhibits purine nucleotide synthesis incorporates itself into the cell's DNA and halts replicationMycophenolate mofetilInosine monophosphate dehydrogenase (IMPDH) inhibitor which impairs guanosine nucleotide synthesisCorticosteroidsNF-κB inhibitorInduces T-cell apoptosis