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M. tuberculosis is inhaled via aerosols into the lung, where they are internalized within alveolar macrophages. Inside nonactivated macrophages (those within the center of the granuloma), mycobacteria (indicated in red) resist destruction, although macrophage activation by T cell-dependent cytokines can overcome this resistance (activated macrophages are believed to reside at the periphery of the granuloma).(https://www.sciencedirect.com/science/article/pii/S1931312808001546...