問題詳情

12.下列何種情況會增加gentamicin腎臟毒性的發生？
(A)peak level ＞ 8 mg/L
(B)trough level ＞ 2 mg/L
(C)peak level ＞ 4 mg/L
(D)trough level ＞ 0.5 mg/L

參考答案

答案：B
難度：適中0.686047
統計：A(21),B(59),C(5),D(1),E(0)

用户評論

【修羅特】評論

毒性指標:peak12 , trough2  (mg/L)

【袁偉智】評論

資料來自 Uptodate：Gentamicin US warning boxMonitor serum concentrations of aminoglycosides when feasible to ensure adequate levels and to avoid potentially toxic levels. When monitoring gentamicin peak concentrations, adjust dosage so that prolonged levels above 12 mcg/mL are avoided. When monitoring gentamicin trough concentrations, adjust dosage so that levels above 2 mcg/mL are avoided. Excessive peak or trough serum concentrations of aminoglycosides may increase the risk of renal and eighth cranial nerve toxicity....

【GE】評論

Gentamicin / Tobramycin DosePeak levelsTrough levelsGram (-) Traditionally5–7 mg/kg IV QD1.6 mg/kg IV Q8H5–8 mg/L<2 mg/LGram (+) 心內膜炎1 mg/kg IV Q8H3–4 mg/L<1 mg/LDose：CrCl ≥60 mL/minNo ChangeTrough levels在大多數情況下將無法檢測到Trough levels 2 mg/L腎毒性風險增加Ref.  Koda-Kimble and Young's Applied Therapeutics：The Clinical Use of Drugs, 10th Edition, P.14...