問題詳情

56.下列因素何者是酒精造成acetaminophen對肝毒性更高的原因?
(A)glutathione存量下降
(B)抑制CYP2E1的活性
(C)抑制CYP2D6的活性
(D)抑制CYP3A4的活性

參考答案

答案:A
難度:適中0.566038
統計:A(180),B(54),C(32),D(52),E(0)

用户評論

joker】評論

資料來源: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014937/Although the possibility remains that chronic consumption of alcohol does increase the risk of paracetamol hepatotoxicity in man (perhaps by impairing glutathione synthesis), there is insufficient evidence to support the alleged major toxic interaction.