【donna】評論

(補充)使用劑量：使用cidofovir前３小時用probenecid 2 g，使用cidofovir後2-8小時使用probenecid 1 gTo reduce possible nephrotoxicity, intravenous prehydration with normal saline and administration of probenecid must be used with each infusing of the antiviral cidofovir. The recommended standard-dose probenecid (SDP) regimen is 2 g at 3 hours before cidofovir, then 1 g at 2 and 8 hours after cidofovir (total 4 g).Ref: https://www.ncbi.nlm.nih.gov/pubmed/12520627

【Chelsea Chen】評論

probenecid 可以抑制腎小管表皮細胞再吸收cidofovir，進而預防cidofovir 的腎毒性；同時又可以抑制細胞主動分泌cidofovir、減緩排除，進而增加cidofovir 的濃度The most important toxicity of the drug is renal which can be reduced by coadministration with saline and probenecid; probenecid blocks active renal tubular secretion (see below). Dosing probenecid prior to, two hours after, and eight hours after cidofovir infusion may result in the doubling of serum concentrations. The fact that probenecid protects against nephrotoxicity and yet decreases renal clearance of the drug, may seem paradoxical. However...