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AbsorptionTrimethoprim/sulfamethoxazole is rapidly absorbed following PO administration. T max is 1 to 4 hr. Steady state is achieved after 3 days.Distribution70% of sulfamethoxazole and 44% of trimethoprim is protein bound. Trimethoprim/sulfamethoxazole is distributed to sputum, vaginal fluid, and middle ear fluid. Trimethoprim/sulfamethoxazole passes the placental barrier and is excreted in human milk.MetabolismMetabolism of sulfamethoxazole is primarily by N 4 -acetylation. The principal metabolites of trimethoprim are the 1- and 3-oxides and the 3- and 4-hydroxy derivatives. The free forms...