【匿名】評論

With the exception of clevidipine, all calcium channel blockers undergo extensive first-pass metabolism in the liver and are substrates for the CYP3A4 isozyme (27,29). Additionally, several of these compounds can inhibit CYP3A4. Clevidipine was designed to have an ultra-short duration of action. Upon IV infusion, clevidipine exerts its antihypertensive actions within 2 to 4 minutes. Rapid ester hydrolysis (Fig. 23.27) inactivates the compound and allows it to be used in patients with either renal or hepatic dysfunction without any dosage adjustments (27).──Foyes 7th P.77...

【♥】評論

含有double-ester容易被水解，短效，可用在肝腎功能差者