37. Which of the following statements about sickle cell anemia is incorrect?
(A) The red blood cells have a crescent shape making them difficult to passthrough the capillaries.
(B) Hb S (sickle hemoglobin) differs from normal Hb A by only one amino acidsubstitution.
(C) The difference between the molecular structures of Hb S and normal Hb A isthe presence of a hydrophobic protrusion on the surface of Hb S protein.
(D) The solubility of dcoxyHb S is lower than that of deoxyHb A, so insolubleHb S fibers may be observed frequently.
(E) When binding with oxygen, Hb S can interact with the cell membrane andcause cell damage.